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Results Summary: While early Phase 2 trials showed promising functional improvements (EX: increased distance walked in the 6 minute walk test in PMM patients), large Phase 3 trials have been complex and have sometimes failed to meet primary endpoints, underscoring the challenge of treating complex mitochondrial disorders

Notably, Curcumin targets NFKB1 and the TNF pathway to suppress inflammation (Wu et al

Moreover, and this is a little-known fact, although the production of melanin is very beneficial in protecting our skin from the sun, it is not without risks and consequences for the cell that produces it (TOBIN, 2008)

Category 2 is used for substances the agency believes may present safety risks, which means compounding pharmacies could not legally prepare those compounds for patient use