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The excess ROS production in aging can initiate the pro-inflammatory generation through activation of multiple transcription factors, including human polynucleotide phosphorylase (hPNPaseold-35), nuclear factor kappa B (NF-B), activator protein 1 (AP-1), specificity protein 1 (Sp1), peroxisome proliferator-activated receptors (PPARs) [49, 50]
CrossRef A Computational Approach to Identify Novel Protein Targets Uncovers New Potential Mechanisms of Action of Mirtazapine S(+) and R() Enantiomers in Rett Syndrome Ottavia Maria Roggero, Nicol Gualandi, Viviana Ciraci, Vittoria Berutto, Emanuele Carosati, Enrico Tongiorgi Journal of Neurochemistry.2025;[Epub] CrossRef ER-36 prevents high glucose-induced cellular senescence and apoptosis in renal tubular cell Dehai Yu, Ling Luo, Yu Liang, Huili Zhou, Yinghui Xiao, Xingna An, Yingzhao Wang, Zhonggao Xu, Weixia Sun, Wanning Wang Frontiers in Endocrinology.2025;[Epub] CrossRef EZH2 in non-cancerous diseases: expanding horizons Renjing Jin, Jianlin Zhang, Yuqing Wang, Ziyu Chen, Xuan He, Xintong Zhang, Zhen Tan, Celina G Kleer, Ye Li, Deli Wang, Lixiang Xue Protein & Cell.2025;[Epub] CrossRef Nuclear receptors in metabolism and diseases: Mechanistic and therapeutic insights Chen-Ying Zhu, Pei-Han Yu, Qi Sun, De-Fei Hong, Chang Yang, Hua Naranmandura Pharmacological Research.2025
Especially in maintaining healthy brain structure, forming new neural connections (plasticity) and supplying raw materials that are used in various brain regeneration processes
