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Research has also found that theobromine has differential contributions to mood and cognitive function compared to caffeine, providing further insight into the distinct yet synergistic nature of these naturally occurring stimulants [34]

Leaky gut, which is characterized by increased intestinal permeability, can exacerbate systemic inflammation and immune responses

Again, though, these actions are largely characterized in cell and animal systems, and their relevance to visible human skin change depends entirely on whether an effective concentration reaches the dermis by the route in question

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