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Learn More: Types of Mutations in DMD How Dystrophin Gene Mutations Cause Muscle Weakness The absence of dystrophin causes progressive muscle damage due to: Increased membrane fragility Calcium influx into muscle cells Activation of destructive enzymes Chronic inflammation This cascade leads to: Muscle fiber degeneration Replacement of muscle tissue with fat and fibrosis Progressive weakness Clinical Impact Children with Duchenne muscular dystrophy typically: Show symptoms before age 5 Experience difficulty walking, running, or climbing stairs Lose ambulation in early adolescence Dystrophin Gene Structure: Why Size Matters The large size of the dystrophin gene is a major reason for its vulnerability to mutations

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By entering the reconstitution volume and desired dose, researchers are presented with the exact draw volume needed in mL and syringe units

Autoimmune disease after alemtuzumab treatment for multiple sclerosis in a multicenter cohort