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Am J Vet Res 67, 1766-1772

Interestingly, studies suggest TrxR inhibitors could also have anti-cancer efficacy due to increased growth rates and elevated cellular ROS from increased mitochondrial respiration that accumulate during accelerated growth resulting in high levels of Trx and TrxR to reduce oxidative stressors (reviewed in Focusing on the common target, each of these compounds have been shown to reduce TrxR enzymatic activity and the inhibition of bacterial growth has been demonstrated with in vitro and in vivo assays

A complex catalysis mechanism, dependent on the presence of NADPH, has been proposed involving three active sites distributed in the TrxR and the Grx domains of the enzyme 30,31

Oxidants can be present in excess concentrations, and free radicals and oxidants give rise to a phenomenon known as OS