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More metabolic parameters, such as fumarate, -KG, GLUT1, glycolytic enzymes (e.g., PKM2, hexokinase, pyruvate dehydrogenase), FAS-associated enzymes (e.g., fatty acid synthase, acetyl-CoA carboxylase), and other amino acids (e.g., tryptophan, methionine), also undergo significant alteration in the metabolic adaptation of macrophages [24, 303,304,305,306] and can serve as theoretical targets for innovative therapies

Moreover, the activation of multiple mechanisms associated with MAP kinases leads to the activation of the NFB transcription factor and induces an inflammatory reaction [22, 54]

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