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Mitochondrial dysfunction itself can be categorized into two types: the first type represents a mutation of a gene which is associated with the ATP-generating pathway, while the second one is related to various abnormalities such as genetic, biochemic or metabolic, that may weaken the ability of the mitochondria to produce ATP (Haas et al., 2007)

B.El MouhriG.El HabbaniR.MohimM.LahrichiA

In cell culture systems, LAC formed in mitochondria is transported into cytosol and enters nucleus becoming a source of acetyl groups for histone acetylation [38]