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The mitogen-activated protein kinase (MAPK) family comprises three major subfamilies with distinct and sometimes opposing functions: extracellular signal-regulated kinase 1/2 (ERK1/2), c-Jun N-terminal kinase (JNK), and p38 MAPK

Chen, C.-L., Lin, C.-F., Chiang, C.-W., Jan, M.-S

In addition, we found that the downregulation of ACs metabolism-related genes and protein expression by VPA in both mouse liver and hepatocytes was dose-dependent, i.e., the greater the VPA concentration, the more pronounced the downregulation effect