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CPT1A , the rate-limiting enzyme in fatty acid oxidation (FAO) that provides an alternative energy source for the survival of cancer cells, plays a crucial role in metabolic adaptation in cancer pathogenesis (108)

To mitigate the effect of NETs on DVT formation, we can minimize the formation of DNA and histones or secrete enzymes that break down or regulate NETs, such as the inhibition of PAD4 (231)

doi: 10.1073/pnas.050004797 83 HoltzmanD

When the gut microbiota is disordered and the intestinal epithelial barrier is damaged, immune cells recognize a variety of bacterial components through pattern recognition receptors to recognize highly conservative pathogen-associated molecular patterns, leading to systemic and tissue-specific inflammation [345]