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This effect results from Depo-Proveras suppression of ovulation combined with thinning of the endometrial lining , making bleeding less likely to occur

doi: 10.1016/j.aquaculture.2016.07.004 18 PrezSnchezJSimMirabetPNayaCatalFMartosSitchaJAPereraEBermejoNogalesAet al

Clinical signs are indistinct and include lethargy, depression, ataxia, anorexia and intermittent vomiting, and in severe cases, can induce neurological disease and blindness in cats