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Grant, and C

While cobalt occurs naturally in the soil, it does not do so predictably

We previously demonstrated that growth attenuation of rv1127c in propionate is rescued by the addition of either vitamin B 12 or acetate (Basu et al, 2018), data that phenocopies Mtb mutants lacking MCC enzymes (Lee et al, 2013), thus supporting an unexpected role for Rv1127c in the MCC (Borah et al, 2021)

Subcutaneous pellets, implanted under the skin every few months, provide another long-acting choice, though they require a minor office procedure for insertion and removal