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Moreover, BRD4 protects mitochondria by safeguarding the transcription of mitochondrial genes located in the nucleus (Kim et al., 2020)

In A549 NRF2 KO cells, GSH was reduced by 73% ( p = 0.013, n = 4 independent experiments), which corresponded to an 82% decrease in [ 18 F]FSPG retention compared to WT A549 cells (1.3 0.3% radioactivity/mg protein vs

Animal studies administering 5-Amino-1MQ orally to diet-induced obese mice have shown dose-dependent reductions in body weight (typically 10-30% reduction compared to vehicle-treated obese controls over 4-12 week treatment periods), with the weight loss primarily reflecting fat mass reduction while lean mass is preserved or even increased

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