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Triptolide, a diterpenoid isolated from Tripterygium wilfordii , has been shown to inhibit NRF2 and HIF-1 expression in myeloid leukemia cells 189

doi: 10.1146/annurev-cellbio-100617-062608 310 DanemanRPratA

If a patient cant tolerate allopurinol and meets the criteria (see above) for probenecid, that can be tried

While DNA nanoplatforms offer high programmability and molecular precision, challenges such as high costs, low throughput, and complex purification processes persist in large-scale manufacturing