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This review aims to clarify what distinguishes the concept of exercise mimetics from broader pharmacology by proposing a systems-informed framework and a pathway hierarchy that connects exercise mimetics to molecular programs, biological functions, and clinically actionable outputs

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In the matrix, the metallo--lactamase-family RNase ELAC2 requires zinc for tRNA 3-end processing, a key step for mitochondrial translation and the assembly of respiratory complexes 85