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Oral administration introduces variability from incomplete absorption and hepatic metabolism, which conflicts with controlled study design

PLoS one 8:e67454 Welsh N, Margulis B, Borg LA, Wiklund HJ, Saldeen J, Flodstrm M, Mello MA, Andersson A, Pipeleers DG, Hellerstrm C et al (1995) Differences in the expression of heat-shock proteins and antioxidant enzymes between human and rodent pancreatic islets: implications for the pathogenesis of insulin-dependent diabetes mellitus