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Since causal relationships of specific key genes in a metabolic pathway can be cell type-specific and comorbidity-dependent, the impact of cell-specific metabolic changes must be thoroughly explored in vivo , with a focus on also systemic effects

doi: 10.1136/gutjnl-2023-330995 118 ZilleMKaruppagounderSSChenYGoughPJBertinJFingerJet al

Evidence shows a U-shaped relationship between iron and cardiovascular outcomes, emphasizing the importance of markers like transferrin saturation, soluble transferrin receptor, and hepcidin

450 The main role of corticosteroids is to inhibit a variety of inflammatory molecules such as cytokines, pro-inflammatory proteins, adhesion molecules and inflammatory receptors, which explain their high efficacy in complex inflammatory diseases