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Notably, trophoblast cells may respond to maternal immune dysregulation by upregulating Fas ligand (FASL) and tumor necrosis factor receptors (TNFRs), thereby triggering apoptotic signaling and promoting trophoblast dysfunction (51)

Activity of selective fully human agonistic antibodies to the TRAIL death receptors TRAIL-R1 and TRAIL-R2 in primary and cultured lymphoma cells: induction of apoptosis and enhancement of doxorubicin- and bortezomib-induced cell death