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When combined with alpha-lipoic acid, some early research has shown that benfotiamine may enhance effects in reducing pain and improving nerve conduction in people with diabetic neuropathy.8 The synergy likely stems from their complementary mechanisms: benfotiamine helps manage glucose-induced damage, while ALA reduces oxidative stress and improves blood flow

This anti-inflammatory action is mediated through several signalling pathways, including the inhibition of the nuclear factor kappa B (NF-B) pathway, contributing to the reduction of liver inflammation associated with NAFLD

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