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10.1038/s41573-021-00233-1 35 FreitasF

Angiotensin, 5-HT (serotonin), and ACh (acetylcholine) are all critical molecules, and their role will be highlighted below

Concurrently, lactate accumulation contributes to an acidic tumor microenvironment that impairs T cell effector function, induces exhaustion, and suppresses proliferation [83]