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The narrative argues for the existence of viable alternatives to mainstream treatments and urges patients to consider these options

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The most frequently reported include nausea, constipation , diarrhea , headaches , fatigue , and body aches

Within the framework of clinical trial design, predictive modeling based on imaging, body fluid biomarkers, genetics, and digital signals can enhance participant selection, identify fast progressors or treatment-responsive subgroups, and enable real-time adaptive modifications to trial parameters