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Within this context, PERK signaling again emerges as a key determinant of therapy resistance

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Moreover, 4-hydroxy-2-nonenal (HNE), a major ,-unsaturated aldehyde product of n-6 fatty acid oxidation, is involved in metabolic and neurodegenerative diseases, inflammatory diseases, and cancer ( Figure 3 Role of cysteine residues for inhibitors targeting protein kinases and phosphatases PTMs can control the biological function of numerous phosphatases, kinases, and transcription factors, which can alter the intracellular localization of target proteins or their interaction with binding partner proteins