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In experimental stroke models, platelet aggregometry and thromboelastography (ROTEM) demonstrated activity of vWF that cross links platelets in arterial thrombi, the end product of the coagulation cascade that promotes clot formation [34]

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The lack of consistent changes in expression of Class I alleles in human or murine PCa cells suggests that the Class I upregulation and consequent CD8-dependent immune response reported in IGF-depleted or inhibited tumors 13,19 may be due not to reduced expression of MHC -chains, but rather to disruption of peptide transport and processing, and downregulation of invariant Class I component 2M

Public docket FDA-2025-N-6895: Open for written comments through July 22, 2026, the day before the meeting convenes