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Causes of deficiency may include inadequate dietary intake, reduced absorption due to medical conditions, and excessive use of medications that deplete the bodys magnesium stores

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Moreover, overexpression of mucin MUC13 exacerbates TJ dysfunction through the janus kinase 1 (JAK1)/signal transducer and activator of transcription 3 (STAT3) and rho-associated coiled-coil containing protein kinase 2 (ROCK2)/mitogen-activated protein kinase (MAPK) signaling pathways, and IL-22 can activate these pathways [73]

Apart from confirming the importance of the phosphorylation sites, we identified three sites in the N-terminal flaking region as key only for the phosphorylated variant, i.e., E163 (when mutated to S, G, T, H, or R), different mutations at the positions L166 (especially substitutions to I, M, F or R), and K167 when mutated to small, aromatic, or negatively charged residues