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doi: 10.1590/0074-02760140266 30 RamosG

A very high hemoglobin level can cause blood to thicken, thereby increasing the risk of stroke, heart attack and organ damage

compared CA cream with MKF, and CA treatment was able to decrease the mMASI score to a greater degree.[80] Reduction in MASI was also found comparable to TXA mesotherapy with less complications observed with the CA group.[86] CA cream with a good efficacy and safety profile may be considered an alternative treatment option for melasma

Producers of those products should consider either denaturing the FBP or replacing folic acid with 5-methyl-THF as fortificant