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In preclinical studies, healthy mice, CKD rats, and diabetic mice treated with NA, NAM, or NMN showed increased NAD + levels in the kidney 297299

However, the current clinical evidence base remains predominantly preclinical, with limited human clinical data available

Our study also found no differences in prolonged 3% NaCl infusion times, total fluid amount, or length of stay in severe hyponatremia between the proactive and reactive DDAVP strategies, which contrasts with previous literature 19