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In particular, the presence of CDS variants in genes that regulate or interact with the Hippo signalling pathway ( Par-1 (missense mutation), misshapen (frameshift mutation)), together with the elongated midgut observed in Abx-treated SL flies, suggests that midgut elongation was potentially influenced by these variants (Supplementary Data 11, Figs

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significantly, the inhibition of autophagy with bafilomycin abrogated this sensitization, and the CXCR4 antagonist AMD3100 demonstrated a synergistic effect with DOX in vivo