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Although there is currently no curative treatment available for melasma, this manuscript critically reviews the knowledge regarding photoprotection, topical and oral therapies, and procedures such as peelings, laser, and microneedling that represent the main strategies for control and prevention of this disease

[DOI] [PMC free article] [PubMed] [Google Scholar] 48.Antioxidant vitamins and mortality in older persons: findings from the Nutrition add-on study to the Medical Research Council trial of assessment and management of older people in the community

Therefore, some amino acids with beneficial immune modulatory effects have been used for fortifying foods such as immunity regulators to enhance the immune system functions (122)

However, the critical limitation remains the near-total absence of rigorous human clinical trial data