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Upon overexpression via adenoviral vectors such as Ad.mda-7, IL-24 accumulates in the ER/Golgi of cancer cells, triggering ER stress, ROS generation, ceramide production, and activation of pro-apoptotic pathways including p-eIF2, ATF4, Bax/Bak, Fas/FasL, and tumor suppressors such as SARI or AIF [65]

On the other hand, creams or lotions are less invasive but might require consistent application over an extended period with potentially slower results

10.1007/s13346-015-0219-1 166 TowiwatP.ChhanaA.DalbethN

For example, monocytes exposed to alcohol can release exosomes carrying miR-27a, which in turn acts as a programming signal to stimulate the polarization of naive monocytes into M2 macrophages [78]