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This structural damage further impairs ATP production, leading to the hallmark symptom of ME/CFS: post-exertional malaise (PEM), a severe exacerbation of symptoms following even minor physical or cognitive exertion

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This leads to cytosolic mtDNA accumulation, which activates the cGASSTING pathway, driving proinflammatory cytokine production

Where appropriate, we can arrange testing or review recent blood results before treatment