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One often overlooked aspect is the intricate relationship between alcohol and essential nutrients, such as Vitamin B12

This phenomenon highlights the importance of the complete peptide for proper enzyme activity ( Figure 2 As per our knowledge, 132 mutations have been reported in MTHFR gene that may cause several disorders such as homocystinuria, anencephaly, tetralogy of Fallot with cleft lip/palate, MTHFR deficiency, acute aortic dissection, reduced enzyme activity, association with preeclampsia, increased erythrocyte folate, respiratory failure and hypotonia, coronary heart disease, Ehlers-Danlos syndrome IV, and Facial palsy ( MTHFR gene has been compiled in Supplementary Table 1

Given its role in cell metabolism and creation, vitamin B12 is crucial to brain health

Remacha et al., 2014)