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8 Thus, we speculate that most AR - BCL-2 + CRPC cells are derived from ARPI-induced reprogramming 2,3,4,5,6,7,8 of AR + BCL-2 - cells that dominate the primary tumors, although pre-existing basal-like PCSCs 14,15 may also preferentially survive ARPIs and other therapies and therefore become selected for and expanded contributing to increased AR - BCL-2 + cell population in CRPC