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For example, activation of GF receptors activates PI3K, either through the stimulation via the regulatory subunit bound to the receptor or through adapter molecules such as the insulin receptor substrate (IRS) proteins

Intracellular antioxidant system of melanocytes Due to the high risk of melanocytes exposure to harmful and prooxidant factors of the external environment, these cells are characterized by naturally well-developed complex antioxidant systems, including enzymatic and non-enzymatic antioxidants (Fig

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Inosine monophosphate dehydrogenase (IMPDH), the rate-limiting enzyme in de novo guanine nucleotide biosynthesis, has gained particular attention (Hackstein and Thomson, 2004