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Accordingly, diverse BTKi are currently under study for both RRMS and PPMS in ongoing clinical trials, the most advanced ones being evobrutinib and tolebrutinib (184)

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Despite these shared traits, GS-S transferases coded for by the same genotype can have differing (though occasionally overlapping) substrate specificity and activity depending on the tissue they are found in and there is much research trying to discover what effect these genetic differences may have on an individuals idiosyncratic response to certain substances such as carcinogens

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