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In addition, TNF-, IL-1, and IL-6 can stimulate each others production and act synergistically through positive feedback loops, thereby amplifying inflammatory signaling ( Cytokines are also important regulators of blood-brain barrier (BBB) integrity

Many infertile males have low testosterone levels [9], which can be due to a decrease in the activities of Star , Cyp11a1 , and Hsd17b3 in Leydig cells [10]