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Importantly, therapeutic manipulation of any single node in this circuit yields highly variable outcomes that depend on tumor type, microenvironmental pressures, therapy modality (ICB versus ACT), and timing of intervention

Blood 85 OpokaR

Although cruciferous vegetables are rich in numerous phytochemicals, their potential anti-cancer activity has been mainly attributed to their contents of natural compounds called glucosinolates [37]

Additional post-translational modifications encompassed by the invention include, for example, e.g., N-linked or O-linked carbohydrate chains, processing of N-terminal or C-terminal ends), attachment of chemical moieties to the amino acid backbone, chemical modifications of N-linked or O-linked carbohydrate chains, and addition or deletion of an N-terminal methionine residue as a result of prokaryotic host cell expression