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Conclusion: In this multicenter study, lean patients with MASLD had a higher mortality and higher incidence of CVD and MACE despite lower DM incidence compared to non-lean individuals with MASLD

Diabet Med 27(9):977987 Enomoto T, Usuki J, Azuma A, Nakagawa T, Kudoh S (2003) Diabetes mellitus may increase risk for idiopathic pulmonary fibrosis

The main related signaling pathways and transformation factors are summarized as follows: NF-B, MAPK signaling pathway, JAK2/STAT3 signaling pathway, PI3K/Akt signaling pathway, AP-1, Nrf2, SIRT1, and HIF-1