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Many cases are reversible or manageable once the underlying cause is identified and treated under medical guidance Supplement or IV therapy may be recommended in certain cases to correct deficiencies or reduce oxidative stress

Maintaining adequate glutathione levels depends on the availability of glutamine and cysteine, two crucial amino acids needed for its synthesis

Vitamin B12 deficiency in the longer run can lead to nervous system disorders with sensation changes, loss of power or co-ordination, gut disorders and (rarely) dementia or mental illness

An additional possibility would be the transfer of haem-bound NO to a free thiol group