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Results vary, but many patients notice gradual improvements when the peptide is combined with healthy eating and regular physical activity

While the liver has substantial storage capacity, supraphysiological doses (such as from injections) are largely excreted in the urine

Standard cycles in this context typically run 8 to 12 weeks, with maximum continuous use up to 16 weeks and a 4 to 8 week break before any repeat cycle

By dosage, the mean changes were: 500 mcg: 127% 750 mcg: 176% (single study) 1,000 mcg: 280% 1,500 mcg: 310% 2000 mcg: 260% 5,000 mcg: 62% While 1,500 mcg of vitamin B12 showed the highest average increase, the effect plateaued or declined at higher doses, suggesting a possible saturation of absorption pathways