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In parallel, studies have reported modulation of early growth response-1 (EGR-1) expression and its regulatory partner NAB2, which are involved in cytokine signaling and early extracellular matrix formation during cellular response processes [2]

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Activated protein C however has not been explored for its protection over BBB integrity in the context of MS, but rather for its anti coagulation effects, reducing disease severity in MS models [128]