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Lifesavers Without lifelong B12 shots, patients deteriorate to a point of serious nerve damage and eventual death

The children probably will be more prone for getting enteric viral infections because of typical playing/feeding habit and subsequent overreliance on alcohol-based sanitizers for cleaning the hands

Cons: Needs medical supervision, possible discomfort from injections, and generally higher costs compared to tablets

Clinically, many late-onset MADD patients respond dramatically to high-dose riboflavin (100400 mg/day), confirming residual enzyme function amenable to cofactor restorationclassifying MADD as a prototype FAD-responsive metabolic myopathy (70)