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It significantly inhibited the cell death induced by COM and suppressed the level of E-cadherin, as well as H 2 O 2

Glutamate-induced apoptosis in neuronal cells is mediated via caspase-dependent and independent mechanisms involving calpain and caspase-3 proteases as well as apoptosis inducing factor (AIF) and this process is inhibited by equine estrogens

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Various one-pot synthesis-based PROTACs with different aliphatic, aromatic and rigidified heterobifunctional linkers were synthesized, demonstrating the suitability of one-pot transformation for high-throughput screening