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76 HanoverJ

Differential involvement of mitochondrial dysfunction, cytochrome P450 activity, and active transport in the toxicity of structurally related NSAIDs

Many studies have demonstrated that downregulation of EMT-inducing transcription factors including TWIST1 , SNAI1/SNAIL , SNAI2/SLUG , and ZEB1/2 leads to platinum sensitivity, while upregulation leads to platinum resistance (Supplementary Table S1)