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A phase II nonrandomized trial evaluating mirtazapine, a tetracyclic antidepressant, administered for 8 weeks to cancer patients without depression, reported that mirtazapine-treated patients gained weight and had an improved appetite.[43] In an exploratory study, olanzapine treatment of cancer patients with cachexia who were receiving active chemotherapy showed a nonsignificant trend toward improved weight.[44] Olanzapine has also been used in combination with megestrol acetate in advanced cancer, with results suggesting benefit.[45] It may be useful for patients on chemotherapy who have difficult-to-control nausea and weight loss