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Proc Natl Acad Sci USA 89:1095510959 Stover JF, Schoning B, Beyer TF, Woiciechowsky C, Unterberg AW (2000) Temporal profile of cerebrospinal fluid glutamate, interleukin-6, and tumor necrosis factor-alpha in relation to brain edema and contusion following controlled cortical impact injury in rats

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XO is gradually upregulated throughout the lifespan because of increased oxidative stress, inflammatory conditions, and other disorders

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Detailed descriptions of the results of these studies were collected and discussed in the review by Arytm and Zimecki (2022)

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Acknowledgements We thank the following core facilities at Northwestern University: the Robert H

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