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Once reconstituted, the compound is exposed to hydrolysis, oxidation, and potential microbial contamination, all of which degrade it over time (1)

J Natl Cancer Inst Monogr 2011:128133 Davern I, Timothy J, James LP, Hinson JA, Polson J, Larson AM, Fontana RJ, Lalani E, Munoz S, Shakil AO, Lee WM (2006) Measurement of serum acetaminophen-protein adducts in patients with acute liver failure

GRP78 expression inhibits insulin and ER stress-induced SREBP-1c activation and reduces hepatic steatosis in mice

The mechanisms involve reducing oxidative stress and inflammation by modulating ROS, AP-1, MMP-1/3, IL-1, SOD, CAT, GSH-Px, TGF-1, Smad2/3, and increasing pro-collagen I expression [25]