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Microneedles (MNs) are minimally invasive, micron-scale projections capable of painlessly breaching the stratum corneum (outermost layer of the skin) to enable transdermal delivery of therapeutics or access to interstitial fluid [32, 155, 156]

These perturbations not only compromise intestinal barrier integrity but also exacerbate microinflammatory cascades through lipopolysaccharide (LPS) translocation, establishing a pernicious gut-kidney axis deterioration cycle. Furthermore, gut microbial dysregulation constitutes a cardinal pathogenic determinant in CKD-associated cardiorenal syndrome (CRS), with microbial metabolites such as TMAO compromising cardiac and renal functionality, precipitating inflammatory cascades and fibrogenesis (Zhao B

In oxaliplatin-induced CIPN models, melatonin prevented the loss of mitochondrial membrane potential (m), promoted nerve regeneration in oxaliplatin-challenged Neuro-2a cells and prevented the loss of nitrosation of proteins and antioxidant enzymes by improving nitrooxidative stress mediated by the chemotherapeutic agent oxaliplatin [45] without interfering with oxaliplatin cytotoxic activity in human colon cancer cell lines

Zheng Z, Zeng Y-Z, Ren K, Zhu X, Tan Y, Li Y, et al