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For menopause, peptides modulating neuroendocrine signaling are being trialed for vasomotor symptoms and bone loss, with early data indicating marginal benefit

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However, with the high bioavailability of equol, it should be noted that the biotransformation capacity of isoflavones to form equol in humans is much lower than that of animals (Reference Yuan, Wang and Liu76,Reference Setchell, Brown and Zimmer-Nechemias79)