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It has been demonstrated to be effective in all stages of AD and provides symptomatic relief that can persist for months to years

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however, long-term studies have reported promoter silencing and off-target effects in non-neuronal cells [118]

S100 proteins are typically symmetric dimers, and each subunit contains two helix-loop-helix EF-hand motifs that are separated by a flexible hinge region and flanked by conserved hydrophobic residues at the amino- and carboxy-terminal ends (34) ( Figure 1 )