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pylori ) stands out as a major risk factor for gastric cancer [4], with numerous studies confirming the role of this bacterium in the multistep process of gastric tumorigenesis, as put forward by Correas cascade [5]

For example, spore-forming bacteria, such as Clostridia , can induce the colonic Tregs, rebalance Th1/Th2/Th17 cells and change to a less proinflammatory immunological milieu in the gut (Jia et al., 2017)

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It is noteworthy that the identification of TMC1, originating from studies on genes associated with nonsyndromic sensorineural hearing loss [19], signifies a landmark achievement