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doi: 10.1007/s00401-018-1815-1

In cells exposed to hypoxia or ischemia, hypoxia-inducible factor-1 (HIF-1) is upregulated and acts as a key regulator of more than 70 genes, including TNF- , IL-1 , IL-6 , and IL-12 , promoting their expression to potentially harmful levels [15]

Examples of caffeine-induced palpitations include: Heart racing after multiple cups of coffee Palpitations after consuming energy drinks Irregular heartbeat sensations after taking certain decongestants Pros of identifying caffeine as a trigger: Easily identifiable and modifiable cause Typically resolves when intake is reduced or eliminated Cons of caffeine as a potential trigger: Present in many common foods and beverages Can cause withdrawal symptoms when reducing intake (headaches, fatigue) May be found in unexpected sources (some medications, chocolate, certain pain relievers) Tips for managing caffeine-induced palpitations: Track caffeine intake: Keep a diary of your caffeine consumption to identify your personal threshold for palpitations

Theyre as safe as the ones youd get in medical clinics and health spas.